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Composites Based on Biopolymers and Ag Nanoparticles as Potential Wound Dressing Materials

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dc.contributor.author SIBECHI, Maria-Gabriela
dc.contributor.author LASLĂU, Simina-Andreea
dc.contributor.author DIŢU, Iustina-Petronela
dc.contributor.author NACU, Isabella
dc.contributor.author COJOCARU, Florina-Daniela
dc.contributor.author BUTNARU, Maria
dc.contributor.author Liliana VERESTIUC, Liliana
dc.date.accessioned 2023-11-08T06:52:32Z
dc.date.available 2023-11-08T06:52:32Z
dc.date.issued 2023
dc.identifier.citation SIBECHI, Maria-Gabriela, LASLĂU, Simina-Andreea, DIŢU, Iustina-Petronela et al. Composites Based on Biopolymers and Ag Nanoparticles as Potential Wound Dressing Materials. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 427-436. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_46
dc.identifier.uri http://repository.utm.md/handle/5014/24672
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_46 en_US
dc.description.abstract Nanotechnology is an emergent, rapidly growing field with numerous technical and biomedical applications. With antibacterial properties, silver nanoparticles have been tested in various medical domains, including the treatments of the skin. The paper presents the preparation of negatively charged silver nanoparticles (NP) in presence of olive leaf extracts and the nanoparticles application in formulations as wound dressings (films and porous scaffolds). Nanoparticles were obtained with high stability, negative zeta potential and antioxidant properties. Xanthan/methacrylated xanthan and methacrylated gelatin have been used to prepare films (by drying) and porous scaffolds (by freeze-drying) with inclusions of silver nanoparticles. FT-IR data confirmed the structure and composition of the NPs and prepared scaffolds. Scanning electron microscopy data indicated a homogeneous mixing of polymers and nanoparticles resulting microporous architecture and uniformly distributed pores at low content of NP or some clustering phenomena at increased content of NP. The volume of fluids retained in the prepared materials is highly influenced by the ratio between polymers, respectively by the NP concentration; the swelling degree values varied over a wide range (1000%–6000%). The materials are bioadhesive and the adhesive properties to substrate are strongly dependent by the polymers structuring and their interaction with silver nanoparticles. In vitro cytotoxicity tests (MTT method and calcein assisted fluorescence microscopy) showed that porous materials are cytocompatible. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject silver nanoparticles en_US
dc.subject xanthan en_US
dc.subject methacrylated gelatin en_US
dc.subject films en_US
dc.subject porous scaffolds en_US
dc.subject wound dressings en_US
dc.title Composites Based on Biopolymers and Ag Nanoparticles as Potential Wound Dressing Materials en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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