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Synthesis and Characterization of Self-assembled Hydrogels Based on Amphiphilic Derivates of Chitosan and Gelatin

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dc.contributor.author SIMION, Andreea
dc.contributor.author LUCA, Andreea
dc.contributor.author COJOCARU, Florina-Daniela
dc.contributor.author VERESTIUC, Liliana
dc.contributor.author BALAN, Vera
dc.date.accessioned 2023-11-07T11:51:00Z
dc.date.available 2023-11-07T11:51:00Z
dc.date.issued 2023
dc.identifier.citation SIMION, Andreea, LUCA, Andreea, COJOCARU, Florina-Daniela et al. Synthesis and Characterization of Self-assembled Hydrogels Based on Amphiphilic Derivates of Chitosan and Gelatin. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 407-416. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_44
dc.identifier.uri http://repository.utm.md/handle/5014/24667
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_44 en_US
dc.description.abstract Self-assembled hydrogels based on amphiphilic derivates of biocompatible polymers, prepared through non-covalent interactions, without using chemical cross-linking agents, are receiving great attention as matrix for cells encapsulation. To our best knowledge, there are no studies in the literature regarding the design of self-assembled hydrogels based on a combination between palmitoyl chitosan and palmitoyl gelatin. In this context, this paper is devoted to the synthesis and characterization of self-assembled hydrogels based on amphiphilic derivates of chitosan and gelatin. Palmitoyl-chitosan and palmitoyl gelatin were prepared through the acylation reaction of polymers (chitosan and gelatin) with palmitoyl chloride. Self-assembled hydrogels based on amphiphilic derivatives of chitosan and gelatin were obtained by dropwise adding of the polymer solutions in cell culture media and spherical hydrogels with stable structure and a diameter of 4–5 mm were obtained. The composition of the hydrogels was confirmed by FTIR-ATR spectroscopy and the stereomicroscopy data indicated a porous structure. The hydrogels swelling degree and mechanical features, in terms of elastic modulus were evaluated and the values obtained for elastic modulus, registered in the range between 3801.52 N/m2 and 4577.49 N/m2 are suitable for hydrogels manipulation and their applications in soft tissue engineering. In vitro cytotoxicity tests, pointed out their cytocompatibility that offers future perspectives for applications in 3D-cell culturing and encapsulation. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject self-assembled hydrogels en_US
dc.subject palmitoyl chitosan en_US
dc.subject palmitoyl gelatin en_US
dc.subject encapsulation en_US
dc.title Synthesis and Characterization of Self-assembled Hydrogels Based on Amphiphilic Derivates of Chitosan and Gelatin en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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