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Ionic Crosslinked Biopolymer-Ceramic Beads for Bone Tissue Engineering

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dc.contributor.author COJOCARU, Florina Daniela
dc.contributor.author TOADER, Claudia Valentina
dc.contributor.author DODI, Gianina
dc.contributor.author GARDIKIOTIS, Ioannis
dc.contributor.author CALISTRU, Anca Elena
dc.contributor.author ROTARU, Aurelian
dc.contributor.author BALAN, Vera
dc.contributor.author VERESTIUC, Liliana
dc.date.accessioned 2023-11-07T12:36:11Z
dc.date.available 2023-11-07T12:36:11Z
dc.date.issued 2023
dc.identifier.citation COJOCARU, Florina Daniela, TOADER, Claudia Valentina, DODI, Gianina et al. Ionic Crosslinked Biopolymer-Ceramic Beads for Bone Tissue Engineering. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 417-426. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_45
dc.identifier.uri http://repository.utm.md/handle/5014/24669
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_45 en_US
dc.description.abstract In several situation when bone integrity is prejudiced, advanced regenerative medicine approaches are involved in order to get a good result, being designed and applied synthetic tissue engineered architectures. This rapidly evolving interdisciplinary domain, tissue engineering, is centered on developing three-dimensional scaffolds, which can be prepared from ceramics, polymers or the combination between those two, resulting a complex material mimicking the composition of the natural bone. Among polymers, polysaccharides are a remarkable class, due to the inexhaustible source, great biocompatibility and versatility in terms of processability. Alginate and guar gum, included in this class have the ability to crosslink in the presence of Ca2+ ions, resulting easy to handle beads. Due to the similarity with human inorganic matter, calcium phosphates are used in orthopedy, frequently combined with polymers to overcome one of the main disadvantages of ceramics: brittleness, which negatively influences mechanical behavior. All these aspects being considered, the aim of the study was to obtain alginate–calcium phosphate beads with inclusion of carboxymethyl guar gum nanoparticles as scaffolds for bone tissue engineering and analyze them in terms of morphology and composition (Field Emission Scanning Electron Microscope and Energy-dispersive X-ray Spectrometer), chemical structure (Fourier Transform Infrared Spectrometer) and behavior in simulated body fluids. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject biopolymers en_US
dc.subject calcium phosphates en_US
dc.subject ionic crosslinking en_US
dc.subject tissue engineering en_US
dc.title Ionic Crosslinked Biopolymer-Ceramic Beads for Bone Tissue Engineering en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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