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Synthesis and Study of Dextran:ZincAminomethylphthalocyanine Copolymers for Medicinal Applications

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dc.contributor.author ROBU, Stefan
dc.contributor.author BULMAGA, Petru
dc.contributor.author POPUSOI, Ana
dc.contributor.author BULIMESTRU, Ion
dc.contributor.author LUNGU, Ion
dc.contributor.author POTLOG, Tamara
dc.date.accessioned 2023-11-08T07:16:18Z
dc.date.available 2023-11-08T07:16:18Z
dc.date.issued 2023
dc.identifier.citation ROBU, Stefan, BULMAGA, Petru, POPUSOI, Ana et al. Synthesis and Study of Dextran:ZincAminomethylphthalocyanine Copolymers for Medicinal Applications. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 437-446. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_47
dc.identifier.uri http://repository.utm.md/handle/5014/24673
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_47 en_US
dc.description.abstract This paper describes the synthesis and characterization of a new water-soluble zinc aminomethylphthalocyanine: dextran copolymers for medical applications. Mono-ZnAMPc has been synthesized by the hydrolysis of mono-(carboxybenzamidomethyl) ZnPc in an acidic medium using a closed reaction system. Dextran has been modified with cyclic and acyclic carbonate groups using triethylamine as catalyst. The FTIR spectra of the functionalized polymer show absorptions at 1805 cm−1 and 1745 cm−1 that indicated both cyclic and acyclic ethyl carbonate groups. Grafting of dextran to zinc aminomethylphthalocyanine was performed using ethyl chloroformate. The metal phthalocyanine content in copolymer varies in a range of (10–50) wt %. FTIR spectra of zinc aminomethylphthalocyanine:dextran copolymers indicated the appearance of new vibrations at (3300–3450) cm–1 and (1550–1650) cm–1 in the copolymers that confirm the presence of amide bound. It is found that the copolymers containing (10–30) wt % of zinc aminomethylphthalocyanine: dextran, ratio 1: 1, are water soluble. Also, for the solubilization of the copolymer, the DMSO: H2O mixture was used. The UV–Vis spectra of the developed copolymers showed more broadening of Soret and Q absorption bands in water than in the DMSO: H2O mixture. Mono-aminomethyl substitution enhances the solubility of ZnPcs, and dextran conjugation conferred water solubility. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject zinc phthalocyanine derivatives en_US
dc.subject aminomethyl group en_US
dc.subject dextran:zincaminomethylphthalocyanine copolymers en_US
dc.subject medical applications en_US
dc.title Synthesis and Study of Dextran:ZincAminomethylphthalocyanine Copolymers for Medicinal Applications en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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