dc.contributor.author | PRISACARI, Viorel | |
dc.contributor.author | GURANDA, Diana | |
dc.contributor.author | ROBU, Ștefan | |
dc.contributor.author | RUSNAC, Roman | |
dc.date.accessioned | 2023-11-21T12:28:11Z | |
dc.date.available | 2023-11-21T12:28:11Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | PRISACARI, Viorel et al. Synthesis and Study of Some Compounds with Antibacterial Properties Obtained from Nitrofuran and Chitosan Derivatives. In: 6th International Conference on Nanotechnologies and Biomedical Engineering, ICNBME, September 20-23, 2023, Chisinau: Abstract Book, p. 101. ISBN 978-9975-72-773-0. | en_US |
dc.identifier.isbn | 978-9975-72-773-0 | |
dc.identifier.uri | http://repository.utm.md/handle/5014/24951 | |
dc.description | Only Abstract | en_US |
dc.description.abstract | We report on possibilities to obtain new antibacterial substances based on chitosan polymer materials grafted with nitrofuran, isohydrafural and furacilin derivatives. The antibacterial properties were assessed via the serial dilution method in liquid nutrient medium (2% meat peptone broth), followed by re-cultivation of standard Gram-positive and Gram-negative bacterial cultures on peptone agar for 24 hours. Both composites obtained on the basis of chitosan grafted with isohydrafural or furacilin showed bactericidal activity against a wide range of Gram-positive and Gram-negative microorganisms, varying within the concentration of 75–300 μg/ml. Due to longterm 48 and 72-hour incubation of microbial cultures cultivated on peptone broth, obvious changes in increasing bactericidal activity of both composites were found over time. Thus, the antibacterial substances isohydrafurol and furatsilin among nitrofurans, grafted onto chitosan maleate, retain their bactericidal activity in the range of 75-300 μg/ml, have prolonged antibacterial activity and can be recommended as active substances in the development of new antibacterials. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Universitatea Tehnică a Moldovei | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | antibacterial substances | en_US |
dc.subject | polymer materials | en_US |
dc.subject | nitrofuran derivatives | en_US |
dc.subject | isohydrafural derivatives | en_US |
dc.subject | furacilin derivatives | en_US |
dc.title | Synthesis and Study of Some Compounds with Antibacterial Properties Obtained from Nitrofuran and Chitosan Derivatives | en_US |
dc.type | Article | en_US |
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