Survey of pharmaceutical engineering specialists on tablet quality parameters

Abstract

A survey of pharmaceutical company specialists was conducted to determine their experience of the influence of design operating parameters of equipment on the quality of tablets. According to the survey, the main types of defects were identified: black specks on the tablet,

inconsistent tablet weight, granule sticking to the punch. Possible causes of these issues could include problems with equipment, the machine, or the granulated mass. Black specks may occur due to damaged punch surfaces, improperly adjusted lubrication feed frames, or overly moist

granules. Tablet weight depends on the heterogeneity of the granules, improper feeder operation, or uneven punch movement. Sticking occurs due to a damaged punch surface, excessive moisture in the granules, or uneven pressure on the tablet. To avoid these issues, it is recommended to: correctly adjust the feed frame, reduce lubrication on the upper punches, improve granule quality, reduce rotation speed, adjust the feed frame, increase pressure, and improve granulation quality.