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Improvement of the Antibacterial Activity of Benzylpenicillin in combination with Green Silver Nanoparticles against Staphylococcus aureus

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dc.contributor.author OHANYAN, S.
dc.contributor.author GRABSKI, H.
dc.contributor.author RSHTUNI, L.
dc.contributor.author TIRATSUYAN, S.
dc.contributor.author HOVHANNISYAN, A.
dc.date.accessioned 2020-05-23T07:32:17Z
dc.date.available 2020-05-23T07:32:17Z
dc.date.issued 2019
dc.identifier.citation OHANYAN, S., GRABSKI, H., RSHTUNI, L. et al. Improvement of the Antibacterial Activity of Benzylpenicillin in combination with Green Silver Nanoparticles against Staphylococcus aureus. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 108. ISBN 978-9975-72-392-3. en_US
dc.identifier.isbn 978-9975-72-392-3
dc.identifier.uri https://doi.org/10.1007/978-3-030-31866-6_65
dc.identifier.uri http://repository.utm.md/handle/5014/8333
dc.description Access full text - https://doi.org/10.1007/978-3-030-31866-6_65 en_US
dc.description.abstract The antibiotic resistance crisis is one of the most pressing public health issues worldwide. Nanoparticles (NPs) can offer a promising solution, since they have antibacterial properties, and can act as carriers for antibiotics and natural antimicrobial compounds. The purpose of this work was to study the antibacterial activity of silver nanoparticles, which are obtained by “green synthesis” from O. araratum extract, against S. aureus bacteria, as well as to study their combined action with antibiotic benzylpenicillin. The results show that the antibacterial effect of silver nanoparticles is higher than that of nanoparticles stabilized by the extract on the growth of S. aureus. It has been shown that benzylpenicillin can interact with the allosteric site of penicillin-binding protein 2a. It has also been shown that “green” AgNPs, which include phytocompounds of the extract of O. araratum can enhance the antibacterial effect of benzylpenicillin synergistically. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject green silver nanoparticles en_US
dc.subject nanoparticles en_US
dc.subject Staphylococcus aureus en_US
dc.subject benzylpenicillin en_US
dc.subject antibacterial effects en_US
dc.subject penicillin-binding proteins en_US
dc.subject proteins en_US
dc.title Improvement of the Antibacterial Activity of Benzylpenicillin in combination with Green Silver Nanoparticles against Staphylococcus aureus en_US
dc.type Article en_US


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