Abstract:
For the use of iron oxide nanoparticles (NPs) for medical purposes, they must have the
following properties: low cytotoxicity, bioavailability, the possibility of large-scale
production, etc. Nowadays, there are many approaches for the iron oxide NPs synthesis,
including chemical, biological, physical methods, etc. In this research, a comparative
analysis of the cytotoxicity of iron oxide (Fe3O4) NPs synthesized with chemical and
biological methods was carried out. For chemical Fe3O4 NPs oleic acid was used as a
stabilizer, while for biogenic NPs were used various extracts of O. basilicum. As research
results showed, the synthesized chemical and biogenic NPs do not have any pronounced
cytotoxicity in relation to the studied bacterial strains and human erythrocytes, which
allows them to use for further in vivo studies.