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New Hydrogels Based on Methacrylated Collagen and Hyaluronic Acid for Soft Tissue Engineering

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dc.contributor.author RAICU, A.
dc.contributor.author COBZARIU, I.
dc.contributor.author VASILACHE, A.L.
dc.contributor.author PEPTU, C.A.
dc.contributor.author BUTNARU, M.
dc.contributor.author VERESTIUC, L.
dc.date.accessioned 2021-11-15T10:44:48Z
dc.date.available 2021-11-15T10:44:48Z
dc.date.issued 2021
dc.identifier.citation RAICU, A., COBZARIU, I., VASILACHE, A.L., ș.a. New Hydrogels Based on Methacrylated Collagen and Hyaluronic Acid for Soft Tissue Engineering. In: ICNMBE-2021: the 5th International Conference on Nanotechnologies and Biomedical Engineering, November 3-5, 2021: Program and abstract book. Chişinău, 2021, p. 88. ISBN 978-9975-72-592-7. en_US
dc.identifier.isbn 978-9975-72-592-7
dc.identifier.uri http://repository.utm.md/handle/5014/18043
dc.description Only Abstract. en_US
dc.description.abstract Polymeric hydrogels are soft and hydrophilic materials of great interest for the engineering of soft tissues, as mimicking structures of the extracellular matrix; because of their 3D architecture and biological properties constitute an adequate environment for cells function. Biopolymers like collagen and hyaluronic acid have a good biological response but the mechanical characteristics make necessary the crosslinking of the networks in order to build resistant and easily workable structures. The paper presents preparation of new hydrogels based on methacrylated collagen and methacrylated hyaluronic acid/ hyaluronic acid as natural-based networks with controlled morphology and biointeractivity. FTIR spectra confirmed the proposed structure and the scanning electron microscopy data indicated a porous morphology dependent of the ratio between polymers. The prepared hydrogels are highly swellable, bioadhesive and degradable by enzymes. In vitro cytotoxicity tests revealed a very good material response in contact with cells (fibroblasts). en_US
dc.language.iso en en_US
dc.publisher Universitatea Tehnică a Moldovei en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject polymeric hydrogels en_US
dc.subject hydrophilic materials en_US
dc.subject collagen en_US
dc.subject hyaluronic acid en_US
dc.title New Hydrogels Based on Methacrylated Collagen and Hyaluronic Acid for Soft Tissue Engineering en_US
dc.type Article en_US


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