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Imino-chitosan Hydrogels - Promising Biomaterials for Candida Infections’ Treatment

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dc.contributor.author AILINCAI, D.
dc.contributor.author MARES, M.
dc.contributor.author BOSTANARU, A. C.
dc.contributor.author MARIN, L.
dc.date.accessioned 2021-11-15T11:05:46Z
dc.date.available 2021-11-15T11:05:46Z
dc.date.issued 2021
dc.identifier.citation AILINCAI, D., MARES, M., BOSTANARU, A. C., MARIN, L. Imino-chitosan Hydrogels - Promising Biomaterials for Candida Infections’ Treatment. In: ICNMBE-2021: the 5th International Conference on Nanotechnologies and Biomedical Engineering, November 3-5, 2021: Program and abstract book. Chişinău, 2021, p. 112. ISBN 978-9975-72-592-7. en_US
dc.identifier.isbn 978-9975-72-592-7
dc.identifier.uri http://repository.utm.md/handle/5014/18048
dc.description Only Abstract. en_US
dc.description.abstract Biocompatible hydrogels were synthesized from chitosan and 2-formylphenylboronic acid (2-FPBA), by the acid condensation reaction of chitosan’s amine groups and aldehyde group of 2-FPBA. FTIR and NMR spectroscopy demonstrated that the hydrogelation is a consequence of the formation of reversible imine linkages between the reagents, while wide angle X-ray diffraction proved the highly ordered supramolecular architecture of the obtained hydrogels. The viscoelastic behavior of the hydrogels was evaluated by rheological measurements, performed at human body temperature. The hydrogels were highly elastic, stiff and strong, with a quite high resistance to deformation and a high recovery degree. The morphology investigation by scanning electron microscopy revealed the samples’ porosity, forming sponges-like microstructures, with quite uniform pores size distribution. The antifungal activity of the synthesized hydrogels was evaluated on two Candida strains and the obtained results recommend these materials for the treatment of Candida infections. en_US
dc.language.iso en en_US
dc.publisher Universitatea Tehnică a Moldovei en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject Candida infections en_US
dc.subject imino-chitosan Hydrogels en_US
dc.subject biocompatible hydrogels en_US
dc.title Imino-chitosan Hydrogels - Promising Biomaterials for Candida Infections’ Treatment en_US
dc.type Article en_US


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