Coordination Compounds of Cu(II), Ni(II) Based on Ethyl 4-benzoate Thiosemicarbazons Derivatives of Salicyl Aldehyde. Antimicrobial and Antifungal Properties

Abstract

The article publishes in vitro tests of the antibacterial and antifungal properties of new сoordination compounds of Cu(II), Ni(II) based on ethyl 4-benzoate thiosemicarbazons derivatives of salicyl aldehyde. Two Gram-positive strains were taken as reference strains: Staphylococcus aureus ATCC 25923 and Bacillus cereus ATCC 11778; two Gram-negative strains: E.coli ATCC 25922 and Acinetobacter baumannii BAA-747; three fungal strains: Candida albicans ATCC 10231, Candida krusei ATCC 6258, Cryptococcus neoformans CECT 1043. The best results were recorded at {Ni(HL1)Cl} complex, a selectivity is observed on Cryptococcus neoformans, with CMI = 0.016, CMF

= 0.031 mg/mL and is twice as active as the control substance Nystatin. The purity and structural formula of synthesized compounds was confirmed by thin layer chromatography; IR spectroscopy; 1H, 13C Nuclear Magnetic Resonance Spectroscopy, metal analysis and magnetochemical analysis.