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PEG-ylated Phenothiazine Derivatives. Synthesis and Antitumor Activity

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dc.contributor.author CIBOTARU, S.
dc.contributor.author NASTASA, V.
dc.contributor.author SANDU, A.I.
dc.contributor.author BOSTANARU, A.C.
dc.contributor.author MARES, M.
dc.contributor.author MARIN, L.
dc.date.accessioned 2021-11-17T12:32:16Z
dc.date.available 2021-11-17T12:32:16Z
dc.date.issued 2021
dc.identifier.citation CIBOTARU, S., NASTASA, V., SANDU, A.I., et al. PEG-ylated Phenothiazine Derivatives. Synthesis and Antitumor Activity. In: ICNMBE-2021: the 5th International Conference on Nanotechnologies and Biomedical Engineering, November 3-5, 2021: Program and abstract book. Chişinău, 2021, p. 104-1. ISBN 978-9975-72-592-7. en_US
dc.identifier.isbn 978-9975-72-592-7
dc.identifier.uri http://repository.utm.md/handle/5014/18100
dc.description Only Abstract en_US
dc.description.abstract Phenothiazine based compounds are well known for their successful application in biomedicine. Used for many years for the synthesis of many classes of drugs, in the last two decades the phenothiazine derivatives proved a promising potential for the cancer treatment. Taking into account phenothiazine properties and poly(ethylene glycol) biocompatibility, a series of three new PEGylated phenothiazine derivatives were prepared by grafting PEG chains to the phenothiazine core. The structure of the targeted molecules was confirmed by FTIR and NMR spectroscopy. The capacity of the synthetized compounds to self-assembly in water was studied by DLS and UV-vis techniques. Their biocompatibility was assessed on normal human dermal fibroblasts and five human cancer cell lines. The synthetized compounds proved excellent biocompatibility on normal cells. A concentration dependent cytotoxicity against cancer cell lines was noticed for two of synthesis PEGylated phenothiazine derivatives. In vivo anti-tumor investigations presented high tumor inhibition comparable to traditional drugs. en_US
dc.language.iso en en_US
dc.publisher Universitatea Tehnică a Moldovei en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject PEG-ylated phenothiazine derivatives en_US
dc.subject biomedicine en_US
dc.subject cancer en_US
dc.title PEG-ylated Phenothiazine Derivatives. Synthesis and Antitumor Activity en_US
dc.type Article en_US


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