DSpace Repository

Importanţa testului de transformare limfoblastică - indicator al imunităţii celulare

Show simple item record

dc.contributor.author GOLBAN, Rita
dc.date.accessioned 2023-09-26T08:40:15Z
dc.date.available 2023-09-26T08:40:15Z
dc.date.issued 2015
dc.identifier.citation GOLBAN, Rita. Importanţa testului de transformare limfoblastică - indicator al imunităţii celulare. In: Ştiinţa Agricolă. 2015, nr. 2, pp. 111-114. ISSN 1857-0003; 2587-3202. en_US
dc.identifier.issn 1857-0003
dc.identifier.issn 2587-3202
dc.identifier.uri http://repository.utm.md/handle/5014/24265
dc.description.abstract În lucrare sunt redate rezultatele investigaţiilor ştiinţifice cu privire la efectuarea testului de transformare limfoblastică (LTT) „ in vitro” sub acţiunea antigenilor anticarbunos şi protein purified derivative, ca rezultat al stimulării limfocitelor, celule centrale ale sistemului imunitar. S-a studiat mecanismul blastizării limfocitelor stimulate care proliferează datorită mitozelor acestora şi s-a determinat practic o populaţie celulară ce corespunde numeric şi funcţional unui răspuns imun de un nivel înalt calitativ. De asemenea s-a constatat că, graţie transformărilor blastice, limfocitele părăsesc starea de inactivitate imunologică şi trec în starea cinetică, devenind capabile să producă efecte specifice atât asupra altor celule cu care cooperează, cât şi asupra substratului antigenic declanşator al reacţiilor imunologice. Concomitent, s-au observat tansformări macrofagale active după revaccinare la animalele mai tinere, cu 15,5% blaşti, comparativ cu varianta martor, unde indicele de stimulare a constituit 3,5%. Modificările indicelui de blastizare nespecifică sunt semnificative pentru aprecierea capacităţii funcţionale a limfocitelor. en_US
dc.description.abstract This paper includes scientific research results related to the lymphoblastic transformation test (LTT) “in vitro” under the action of anticarburising antigens and purified protein derivative, as a result of stimulation of lymphocytes which are central cells of the immune system. It was studied the mechanism of the stimulated lymphocytes blastization, which proliferates due to their mitosis and it was practically determined a cellular population, which corresponds numerically and functionally to an immune high quality answer. At the same time, it wasstated that due to blast transformations, lymphocytes leave the stage of immunological inactivity and pass to the kinetic stage, being capable to produce specific effects, both on other cells they cooperate with and on the antigenic substrate, which causes immunological reactions. We have also observed activated macrophage changes after the re-vaccination in young animals with 15.5% of blasts, compared to the reference sample where stimulation indices were 3.5%. Modifications ofthe nonspecific blast are necessary to evaluate the functional capacity of lymphocytes.
dc.language.iso ro en_US
dc.publisher Universitatea Agrară de Stat din Moldova en_US
dc.relation.ispartofseries Ştiinţa Agricolă;2015, N. 2
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject transformare limfoblastică en_US
dc.subject antigene en_US
dc.subject limfocite en_US
dc.subject clone en_US
dc.subject imunitate celulară en_US
dc.subject lymphoblastic transformation en_US
dc.subject antigens en_US
dc.subject lymphocytes en_US
dc.subject clones en_US
dc.subject cell mediated immunity en_US
dc.title Importanţa testului de transformare limfoblastică - indicator al imunităţii celulare en_US
dc.title.alternative Significance of the lymphoblastic transformation test as an indicator of cell immunity en_US
dc.type Article en_US


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

Search DSpace


Advanced Search

Browse

My Account