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Effect of Gold Nanoparticles Functionalized by Arthrospira Platensis on Rats

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dc.contributor.author CEPOI, Liliana
dc.contributor.author RUDI, Ludmila
dc.contributor.author CHIRIAC, Tatiana
dc.contributor.author ZINICOVSCAIA, Inga
dc.contributor.author GROZDOV, Dmitrii
dc.contributor.author RUDIC, Valeriu
dc.date.accessioned 2023-11-07T09:25:57Z
dc.date.available 2023-11-07T09:25:57Z
dc.date.issued 2023
dc.identifier.citation CEPOI, Liliana, RUDI, Ludmila, CHIRIAC, Tatiana et al. Effect of Gold Nanoparticles Functionalized by Arthrospira Platensis on Rats. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 366-375. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_40
dc.identifier.uri http://repository.utm.md/handle/5014/24662
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_40 en_US
dc.description.abstract The influence of unmodified engineered AuNPs versus biofunctionalized by cyanobacterium Arthrospira platensis (spirulina) on rats was studied. Au NPs were administered per os in a quantity of 1 µgAu/day per animal for 28 days, followed by a clearance period of the same duration. The accumulation of nanoparticles in different organs, the change in hematological and biochemical parameters in the experimental animals were assessed at the end of the nanoparticle administration and the clearance periods. The amount of gold accumulated in organs was determined by applying neutron activation analysis at the IBR-2 reactor. Biochemical and hematological analyses of the blood were performed using a semi-automated system StarDust MC15. The biofunctionalized nanoparticles were accumulated in larger amounts, and the amount of metal remaining after the clearance period was also higher in the case of the functionalized nanoparticles. Only biofunctionalized nanoparticles accumulated in the ovaries. Both types of nanoparticles possess high biological activity, inclusive of their induced changes in the leukogram, glucose, urea and liver transaminases levels. More pronounced changes being characteristic for unmodified gold nanoparticles. Tested nanoparticles can cause long-term or delayed effects, which include the increase in glucose and urea levels as well as the increase in ALT activity after the clearance period. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject Arthrospira platensis en_US
dc.subject spirulina en_US
dc.subject gold nanoparticles en_US
dc.subject aurum accumulation en_US
dc.subject aurum clearance en_US
dc.title Effect of Gold Nanoparticles Functionalized by Arthrospira Platensis on Rats en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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