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Mechanical Characterization of Decellularized Blood Vessels: A Valuable Tool to Provide Comprehensive Information About the Scaffold

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dc.contributor.author MALCOVA, Tatiana
dc.contributor.author ROJNOVEANU, Gheorghe
dc.contributor.author CIUBOTARU, Anatol
dc.contributor.author NACU, Viorel
dc.date.accessioned 2023-11-07T10:24:29Z
dc.date.available 2023-11-07T10:24:29Z
dc.date.issued 2023
dc.identifier.citation MALCOVA, Tatiana, ROJNOVEANU, Gheorghe, CIUBOTARU, Anatol et al. Mechanical Characterization of Decellularized Blood Vessels: A Valuable Tool to Provide Comprehensive Information About the Scaffold. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 386-396. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_42
dc.identifier.uri http://repository.utm.md/handle/5014/24665
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_42 en_US
dc.description.abstract Cardiovascular diseases (CVDs) remain an important global health problem. Surgical revascularization (or bypass surgery) has been established as the most optimal therapeutic approach for patients with severe injury; however, not in all cases a suitable vascular substitute can be identified. The field of vascular tissue engineering and regenerative medicine aim to produce suitable tissue-engineered vascular grafts (TEVGs) for vascular repair, replacement, or reconstructive aims. Decellularization (DC) is a promising approach because it completely removes the antigenic cellular components. The goal of the proposed study was to examine the mechanical integrity of the decellularized porcine carotid arteries (a prototype of small-diameter vascular grafts). The developed DC procedure included osmotic shock, chemical surfactant treatment, and enzymatic digestion. Agree to other DC protocols reported previously, we were able to demonstrate, on the one hand, complete removal of cells throughout the arterial wall by performing H&E staining and DAPI, on the other hand, good biomechanical properties of decellularized tissue by performing the suture retention strength testing. The average suture retention strength of native porcine vessels was 1.08 ± 0.39 N. The average suture retention strength of decellularized vessels was 1.14 ± 0.38 N (p = 0.0731). In summary, the both control and treated vessels exhibited similar mechanical properties; the used combined method had beneficial effect in this study. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject decellularization en_US
dc.subject blood vessels en_US
dc.subject cardiovascular diseases en_US
dc.subject tissue-engineered en_US
dc.subject vascular grafts en_US
dc.subject decellularized porcine carotid arteries en_US
dc.title Mechanical Characterization of Decellularized Blood Vessels: A Valuable Tool to Provide Comprehensive Information About the Scaffold en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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