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Comparative Assessment of In Vitro Effects on the Human Lymphocytes in Tuberculosis Patients of the Zinc Oxide Nanoparticles Biofunctionalized by Sulfated Polysaccharides from Spirulina

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dc.contributor.author CHIRIAC, Tatiana
dc.contributor.author LESNIC, Evelina
dc.contributor.author GHINDA, Serghei
dc.contributor.author RUDI, Ludmila
dc.contributor.author CEPOI, Liliana
dc.date.accessioned 2023-11-07T11:13:59Z
dc.date.available 2023-11-07T11:13:59Z
dc.date.issued 2023
dc.identifier.citation CHIRIAC, Tatiana, LESNIC, Evelina, GHINDA, Serghei et al. Comparative Assessment of In Vitro Effects on the Human Lymphocytes in Tuberculosis Patients of the Zinc Oxide Nanoparticles Biofunctionalized by Sulfated Polysaccharides from Spirulina. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 397-406. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_43
dc.identifier.uri http://repository.utm.md/handle/5014/24666
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_43 en_US
dc.description.abstract The in vitro study of the influence of the zinc oxide nanoparticles biofunctionalized by sulfated polysaccharides compared with sulfated polysaccharides used the peripheral blood lymphocytes collected form 65 patients, new cases with pulmonary tuberculosis (TB). The patients were distributed in the main study group, which included 34 cases with multidrug-resistant TB (MDR-TB), divided in the 1st study group with 12 cases with primary drug-resistance and the 2nd study group with 22 patients with acquired drug-resistance during the anti-tuberculosis treatment, and the control group composed by 31 patients with drug susceptible TB The immunological indices were assessed through the lymphocyte’s blast transformation reaction at phytohaemagglutinin and immune modulating index. The experiments demonstrated that the exposure of the lymphocytes to the biologically active compounds - zinc oxide nanoparticles biofunctionalized by sulfated polysaccharides exerted a higher immune stimulating effect compared with the purified sulfated polysaccharides. The biological activity was more pronounced on lymphocytes collected from the patients with primary drug resistance compared with those who acquired the drug-resistance during the anti-tuberculosis treatment and the effect was more pronounced in patients with drug susceptible TB compared with those with drug-resistant TB. The biochemical indicators of the glucose metabolism, identified a low glucose consumption, low activity of the aldolase and lactate dehydrogenase during the lymphocyte’s proliferation test at phytohaemagglutinin, which was increased significantly at the exposure of the lymphocytes to the zinc oxide nanoparticles biofunctionalized by sulfated polysaccharides, and higher in the group of patients with drug-susceptible tuberculosis. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject zinc oxide nanoparticles en_US
dc.subject sulfated polysaccharides en_US
dc.subject spirulina en_US
dc.subject tuberculosis en_US
dc.subject lymphocytes en_US
dc.title Comparative Assessment of In Vitro Effects on the Human Lymphocytes in Tuberculosis Patients of the Zinc Oxide Nanoparticles Biofunctionalized by Sulfated Polysaccharides from Spirulina en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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