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In vivo and in silico Studies of the Neuroprotective Effect of Artemisinin in Prevention of Alzheimer’s Disease in an Animal Model

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dc.contributor.author TIRATSUYAN, Susanna
dc.contributor.author HAMBARDZUMYAN, Yelena
dc.contributor.author POGHOSYAN, Michael
dc.contributor.author DANIELYAN, Margarita
dc.contributor.author HOVHANNISYAN, Ashkhen
dc.date.accessioned 2023-11-14T10:06:48Z
dc.date.available 2023-11-14T10:06:48Z
dc.date.issued 2023
dc.identifier.citation TIRATSUYAN, Susanna, HAMBARDZUMYAN, Yelena, POGHOSYAN, Michael et al. In vivo and in silico Studies of the Neuroprotective Effect of Artemisinin in Prevention of Alzheimer’s Disease in an Animal Model. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 2: Biomedical Engineering and New Technologies for Diagnosis, Treatment, and Rehabilitation, 2023, p. 199-207. ISBN 978-3-031-42781-7. e-ISBN 978-3-031-42782-4. en_US
dc.identifier.isbn 978-3-031-42781-7
dc.identifier.isbn 978-3-031-42782-4
dc.identifier.uri https://doi.org/10.1007/978-3-031-42782-4_22
dc.identifier.uri http://repository.utm.md/handle/5014/24791
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42782-4_22 en_US
dc.description.abstract Currently, artemisinin (ART) and many of its semisynthetic derivatives are considered as potential neuroprotectors. The effect of ART in an animal model of Alzheimer’s disease (AD) induced by aggregated amyloidogenic peptide Aβ1–42 was studied by electrophysiology and morphology analysis to detect changes in brain memory caused by activation of the entorhinal cortex as synaptic potentiation and depression as well as identifying a correlation with in silico studies of the direct interaction of ART with amyloidogenic peptides 5Aβ17–42 and 18Aβ9–40. We have shown the preventive effect of ART in an animal model of AD. Electrophysiological studies showed that in the pre-injection of ART, there is an obvious and significant decrease in excitotoxicity, which precedes both depressor and excitatory post-stimulus effects, approaching normal, indicating its powerful protective effect. Protection was more effective in relation to the depressor sequence. Histo-morphological analysis showed that the preliminary injection of ART acts as a neuroprotective agent that prevents or slows down damage to brain tissue and also promotes the restoration of neurons and their environment. The conducted in silico studies indicate the direct interaction of ART with amyloidogenic peptides 5Aβ17–42 and 18Aβ9–40 with high binding energies. At the same time, ART can stop the formation and growth of the 18Aβ9–40 fibril, as well as destabilize the already formed amyloid, which correlates with in vivo studies. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject Alzheimer’s disease en_US
dc.subject amyloidogenic peptides en_US
dc.subject peptides en_US
dc.subject memory en_US
dc.title In vivo and in silico Studies of the Neuroprotective Effect of Artemisinin in Prevention of Alzheimer’s Disease in an Animal Model en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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