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Synergy Effect of Ascorbic Acid and α-Tocopherol in Kinetic Model of Lipid Peroxidation

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dc.contributor.author KANAROVSKII, Evghenii
dc.contributor.author YALTYCHENKO, Olga
dc.date.accessioned 2023-11-15T10:10:45Z
dc.date.available 2023-11-15T10:10:45Z
dc.date.issued 2023
dc.identifier.citation KANAROVSKII, Evghenii, YALTYCHENKO, Olga. Synergy Effect of Ascorbic Acid and α-Tocopherol in Kinetic Model of Lipid Peroxidation. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 2: Biomedical Engineering and New Technologies for Diagnosis, Treatment, and Rehabilitation, 2023, p. 326-332. ISBN 978-3-031-42781-7. e-ISBN 978-3-031-42782-4. en_US
dc.identifier.isbn 978-3-031-42781-7
dc.identifier.isbn 978-3-031-42782-4
dc.identifier.uri https://doi.org/10.1007/978-3-031-42782-4_35
dc.identifier.uri http://repository.utm.md/handle/5014/24814
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42782-4_35 en_US
dc.description.abstract The synergy effect of α-tocopherol and ascorbic acid (vitamins E and C) is taken into account in the presented theoretical model of the kinetics of the process of lipid peroxidation (LPO). An analysis of the features in the course of the LPO process with the participation of vitamins E and C made it possible to apply the appropriate approximations that simplify the model system of differential equations. For cell membranes, it is characteristic that the lipid substrate and oxygen are in excess, as well as ascorbate, according to experimental data, should be considered in excess. Thus, the concentrations of reagents in excess are constant model parameters. Applying the quasi-stationary approximation to lipid radicals further simplifies the model. The synergy effect is primarily related to the ability of ascorbate to regenerate α-tocopherol, thereby protecting it from both depletion and prooxidant effect. This effect at a given concentration of α-tocopherol is enhanced with increasing concentration of ascorbate, but the ratio of ascorbate and α-tocopherol concentrations should not exceed 100, since at high concentrations the ascorbate is also able to act as a prooxidant. As a result, analytical expressions were obtained for the kinetic curves of vitamin E (in its two forms) and the main LPO product (lipid hydroperoxide). This model is minimal and quite adequately describes the LPO process. The features of the synergy effect of vitamins E and C and its significance for the effective control of the LPO process as a whole are discussed. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject cell membranes en_US
dc.subject lipid peroxidation en_US
dc.subject ascorbic acid en_US
dc.subject antioxidants en_US
dc.subject synergy effect en_US
dc.subject lipid peroxidation en_US
dc.title Synergy Effect of Ascorbic Acid and α-Tocopherol in Kinetic Model of Lipid Peroxidation en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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