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Synthesis and Study of Some Compounds with Antibacterial Properties Obtained from Nitrofuran and Chitosan Derivatives

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dc.contributor.author PRISACARI, Viorel
dc.contributor.author GURANDA, Diana
dc.contributor.author ROBU, Ștefan
dc.contributor.author RUSNAC, Roman
dc.date.accessioned 2023-11-21T12:28:11Z
dc.date.available 2023-11-21T12:28:11Z
dc.date.issued 2023
dc.identifier.citation PRISACARI, Viorel et al. Synthesis and Study of Some Compounds with Antibacterial Properties Obtained from Nitrofuran and Chitosan Derivatives. In: 6th International Conference on Nanotechnologies and Biomedical Engineering, ICNBME, September 20-23, 2023, Chisinau: Abstract Book, p. 101. ISBN 978-9975-72-773-0. en_US
dc.identifier.isbn 978-9975-72-773-0
dc.identifier.uri http://repository.utm.md/handle/5014/24951
dc.description Only Abstract en_US
dc.description.abstract We report on possibilities to obtain new antibacterial substances based on chitosan polymer materials grafted with nitrofuran, isohydrafural and furacilin derivatives. The antibacterial properties were assessed via the serial dilution method in liquid nutrient medium (2% meat peptone broth), followed by re-cultivation of standard Gram-positive and Gram-negative bacterial cultures on peptone agar for 24 hours. Both composites obtained on the basis of chitosan grafted with isohydrafural or furacilin showed bactericidal activity against a wide range of Gram-positive and Gram-negative microorganisms, varying within the concentration of 75–300 μg/ml. Due to longterm 48 and 72-hour incubation of microbial cultures cultivated on peptone broth, obvious changes in increasing bactericidal activity of both composites were found over time. Thus, the antibacterial substances isohydrafurol and furatsilin among nitrofurans, grafted onto chitosan maleate, retain their bactericidal activity in the range of 75-300 μg/ml, have prolonged antibacterial activity and can be recommended as active substances in the development of new antibacterials. en_US
dc.language.iso en en_US
dc.publisher Universitatea Tehnică a Moldovei en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject antibacterial substances en_US
dc.subject polymer materials en_US
dc.subject nitrofuran derivatives en_US
dc.subject isohydrafural derivatives en_US
dc.subject furacilin derivatives en_US
dc.title Synthesis and Study of Some Compounds with Antibacterial Properties Obtained from Nitrofuran and Chitosan Derivatives en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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