Evaluation of the functional activity of T- lymphocytes, concentration of IL-4, IL-10 and IFN-γ at the exposure to bioactive compounds extracted from Spirulina platensis in pulmonary tuberculosis

Abstract

This study presents the results of the influence of bioactive compounds extracted from Spirulina platensis on the functional activity of T-lymphocytes through BTRL by PHA, concentration of IL-4, IL -10 and IFN-γ in patients with pulmonary tuberculosis. The experiments were realised in vitro and were tested sulfated polysiccharides (SPS), BioR and BioRZn. Results: I in patients with allergic reactions to antituberculous treatment BioRZn decreased the BTRL by PHA, but SPS and BioR increased. In patients with toxic and toxic-allergic reactions SPS and BioR increased and BioRZn decreased. In patients with toxic and toxic-allergic reactions the concentration of IFN-γ was higher than in those with allergic reactions but IL-4 was higher in patients with allergic and toxic-allergic reactions. The exposure of the T-lymphocytes to SPS statistically decreased the level of IFN–γ, increased IL-4 and IL-10. Conclusions: obtained data confirmed the utility of SPS, BioR and BioRZ as remedies for pathogenic correction of disturbances caused by adverse drag events developed during the anti-tuberculous treatment in patients with pulmonary tuberculosis.