The impact of the coordinative compounds, thiosemicarbaside derivates on the oxidative stress indices in ex vivo experiments

Abstract

Aim: to study the influence of the new copper coordinative compounds, thiosemicarbaside derivatives, coded as CMA-181, CMC-34, CMD-8, CMG-41 andCMJ-33 on the OS indices in ex vivo experiments. Material and methods: the new CCC, thiosemicarbaside derivatives, coded as CMA-18, CMC-34, CMD-8, CMG-41, and CMJ-33 developed at the State University of Moldova in the Laboratory "Advanced materials in biopharmaceutical and technical" were evaluated in several ex vivo experiments in 2 concentrations – 1,0 and 10,0 mM/L, in which was used the peripheral blood samples collected from 8 conventionally healthy individuals. The markers of OS were assessed the activity of malondialdehyde (MAD), superoxide dismutase (SOD) and catalase (CAT). Conclusions: The influence of studied CCC on the OS indices was selective and differentiate. Further studies are needed to evaluate the mechanisms of action in other biosystems and experiments.