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The impact of the coordinative compounds, thiosemicarbaside derivates on the oxidative stress indices in ex vivo experiments

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dc.contributor.author PANTEA, V.
dc.contributor.author LESNIC, E.
dc.contributor.author ANDRONACHE, L.
dc.date.accessioned 2024-02-09T08:59:58Z
dc.date.available 2024-02-09T08:59:58Z
dc.date.issued 2022
dc.identifier.citation PANTEA, V., LESNIC, E., ANDRONACHE, L. The impact of the coordinative compounds, thiosemicarbaside derivates on the oxidative stress indices in ex vivo experiments. In: International Scientific Conference on Microbial Biotechnology, 5th edition, Chișinău, Moldova, October 12-13, 2022. Chişinău, 2022, p. 97. ISBN 978-9975-3555-6-8; ISBN 978-9975-3555-7-5. en_US
dc.identifier.isbn 978-9975-3555-6-8
dc.identifier.isbn 978-9975-3555-7-5
dc.identifier.uri https://doi.org/10.52757/imb22.65
dc.identifier.uri http://repository.utm.md/handle/5014/26332
dc.description This study was supported by the State Program (2020-2023) of the Republic of Moldova (research grant No. 20.80009.5007.10) en_US
dc.description.abstract Aim: to study the influence of the new copper coordinative compounds, thiosemicarbaside derivatives, coded as CMA-181, CMC-34, CMD-8, CMG-41 andCMJ-33 on the OS indices in ex vivo experiments. Material and methods: the new CCC, thiosemicarbaside derivatives, coded as CMA-18, CMC-34, CMD-8, CMG-41, and CMJ-33 developed at the State University of Moldova in the Laboratory "Advanced materials in biopharmaceutical and technical" were evaluated in several ex vivo experiments in 2 concentrations – 1,0 and 10,0 mM/L, in which was used the peripheral blood samples collected from 8 conventionally healthy individuals. The markers of OS were assessed the activity of malondialdehyde (MAD), superoxide dismutase (SOD) and catalase (CAT). Conclusions: The influence of studied CCC on the OS indices was selective and differentiate. Further studies are needed to evaluate the mechanisms of action in other biosystems and experiments. en_US
dc.language.iso en en_US
dc.publisher Institute of Microbiology and Biotechnology, Republic of Moldova en_US
dc.relation.ispartofseries International scientific conference "Microbial Biotechnology", 5th edition, 12-13 October 2022, Chisinau, Republic of Moldova;
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject in vivo experimentation en_US
dc.subject malondialdehyde en_US
dc.subject oxidative stress en_US
dc.title The impact of the coordinative compounds, thiosemicarbaside derivates on the oxidative stress indices in ex vivo experiments en_US
dc.type Article en_US


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