Comparative analysis of biocompatibility of chemical and biogenic Fe3O4 nanoparticles

Abstract

Due to their unique physicochemical and biological properties, the application of nanoparticles (NPs) in medicine opens up new possibilities for enhancing the effectiveness of diagnosis and treatment of various diseases, including tumors. Numerous data regarding the biological properties of iron oxide NPs demonstrate their potential for biomedical research, and the use of green synthesis methods leading to the formation of biocompatible biogenic NPs contributes to expanding the scope of their research. The aim of this study was to investigate the complex impact profile of biogenic and chemically synthesized paramagnetic Fe3O4 NPs of the core-shell structure with the anticancer drug fluorouracil (Accord, UK).