DSpace Repository

Optimization of light action spectra for porphyrins in vivo

Show simple item record

dc.contributor.author BARUN, V.
dc.contributor.author DICK, S.
dc.contributor.author SONTEA, V.
dc.contributor.author ABRAMOVICH, N.
dc.contributor.author SERYAKOV, A.
dc.date.accessioned 2019-10-17T08:54:44Z
dc.date.available 2019-10-17T08:54:44Z
dc.date.issued 2014
dc.identifier.citation BARUN, V., DICK, S., SONTEA, V., ABRAMOVICH, N., SERYAKOV, A.. In: Microelectronics and Computer Science: proc. of the 8th intern. conf., October 22-25, 2014. Chişinău, 2014, pp. 417-420. ISBN 978-9975-45-329-5. en_US
dc.identifier.isbn 978-9975-45-329-5
dc.identifier.uri http://repository.utm.md/handle/5014/4768
dc.description.abstract Light action spectra for main skin chromophores are simulated. Porphyrins are selected as target chromophores. They can produce singlet oxygen (SO) reactions under tissue irradiation, which acts as a natural photosensitizer. The SO is toxic for, e.g. cancer cells. This process is known to be widely used in photodynamic therapy (PDT). It is shown by way of examples that skin irradiation by red light, where the porphyrins have local maxima of light absorption, can improve the generation of SO as compared with the irradiation at a wavelength corresponding to the absolute maximum of light absorption. Taking etio- and rhodoporphyrin as target chromophores, we obtained that the said improvement of SO generation can be about 5 to 100 times at specific depths inside tissue and 10 to 20 times integrally for the whole dermis thickness. The presented results can provide new opportunities for the selection of the irradiation wavelengths under application of traditional PDT methods. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject multi-layered biological tissues en_US
dc.subject singlet oxygen en_US
dc.subject porphyrins en_US
dc.subject radiative transfer equation en_US
dc.subject light action spectra en_US
dc.title Optimization of light action spectra for porphyrins in vivo en_US
dc.type Article en_US


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

Search DSpace


Advanced Search

Browse

My Account