In silico study of sulforaphane interaction with LasR of P. aeruginosa

Abstract

One of the most important public health challenges of the 21st century is the search of new preventive or therapeutic anti-infective strategies, based on a combination of the plant-derived quorum-sensing inhibitors (QSI) with anti-inflammatory agents, and immunomodulators without pressure on the selection factors and the effect of dysbiosis [1]. Among the family Brassicaceae crucial secondary metabolites are isothiocyanates, such as sulforaphane (SFN), erucine etc. which have anticancer, anti-atherogenic, hepatoprotective, antimutagenic, antioxidant, antifungal, antibacterial, and bioherbicidal activities [2, 3].