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Micro-Spectroscopy of Single Erythrocytes Infected with the Malaria Parasite

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dc.contributor.author ARORA, Silki
dc.contributor.author PARK, Sang Hoon
dc.contributor.author MAUSER, Jennifer
dc.contributor.author CHAKRABARTI, Debopam
dc.contributor.author SCHULTE, Alfons
dc.date.accessioned 2019-10-25T11:02:35Z
dc.date.available 2019-10-25T11:02:35Z
dc.date.issued 2011
dc.identifier.citation ARORA, Silki, PARK, Sang Hoon, MAUSER, Jennifer. Micro-Spectroscopy of Single Erythrocytes Infected with the Malaria Parasite. In: ICNBME-2011. International conference on Nanotechnologies and Biomedical Engineering. German-moldovan workshop on Novel Nanomaterials for Electronic, Photonic and Biomedical Applications: proc. of the intern. conf., July 7-8, 2011. Chişinău, 2011, pp. 252-254. ISBN 978-9975-66-239-0. en_US
dc.identifier.isbn 978-9975-66-239-0
dc.identifier.uri http://repository.utm.md/handle/5014/5298
dc.description.abstract The erythrocytic cycle of the malaria parasite Plasmodium falciparum is marked with structural, mechanical and biochemical modifications to the host red blood cell. The parasite degrades the hemoglobin of the host cell and hydrolyzes it into hemozoin. We investigate healthy and infected erythrocytes using micro-Raman and spatially resolved absorption spectroscopy. The electronic absorption spectrum of a single cell is measured and spectral changes are related to the parasite life cycle. The Soret absorption band in the trophozoite stage is shifted to higher wavelength by 3 nm. The findings are compared with micro-Raman spectra that show consistent changes in the heme vibrations. Micro-absorption may offer a potential diagnostic marker for identifying pathological states accompanying malaria. en_US
dc.language.iso en en_US
dc.publisher Technical University of Moldova en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject microscopy en_US
dc.subject diagnostics en_US
dc.subject erythrocyte en_US
dc.subject malaria parasite en_US
dc.subject Raman spectroscopy en_US
dc.subject spectroscopy en_US
dc.title Micro-Spectroscopy of Single Erythrocytes Infected with the Malaria Parasite en_US
dc.type Article en_US


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