The dynamics of the vascular wall changes evolution in the lumbar intervertebral disc. Insights

Abstract

Atherosclerosis is one of the etiological factors to initiate degeneration disc studied in detail by histological investigations stained with haematoxylin-eosin and immunohistochemical examination with antibodies CD34, in immunohistochemical laboratory from Timisoara, leader Marius Raica. Were examinated of 20 sample harversted from the L1-L5 vertebral arteries from cadavers with different cardiac pathologies as a couse of a death, age and sex from "Sfînta Treime" hospital. Atherosclerosis with vascular wall thickening affects the structureand viability of intervertebral disc, initially being affected nucleus pulposus, annulus fibrosis and then through a series of mechanisms it splits fragmented collagen fibers, and finally fibroblast proliferation with sclerosis. In five cases the vertebral arteries were affected, lacking intimate vascular event (5%), in three cases, faint, moderate; in ten cases-handed (50%), and in 6 casespreserved. Currently modern technologies remain in the assessment of new methods of treatment and prevention of degenerative-dystrophic changes.