DSpace Repository

Experimental cell therapy in type I diabetes

Show simple item record

dc.contributor.author NACU, Victoria
dc.contributor.author TRIFAN, Victoria
dc.contributor.author LÎSÎI, Cornel
dc.contributor.author COROBCIUC, Alexei
dc.contributor.author BITCA, Angela
dc.contributor.author NACU, Viorel
dc.contributor.author DUMITRU, Vartic
dc.contributor.author NACU, Viorel
dc.date.accessioned 2019-10-25T12:35:10Z
dc.date.available 2019-10-25T12:35:10Z
dc.date.issued 2013
dc.identifier.citation NACU, Victoria, TRIFAN, Victoria, LÎSÎI, Cornel, COROBCIUC, Alexei, BITCA, Angela, DUMITRU, Vartic, NACU, Viorel. Experimental cell therapy in type I diabetes. In: ICNBME-2013. International Conference on Nanotechnologies and Biomedical Engineering. German-Moldovan Workshop on Novel Nanomaterials for Electronic, Photonic and Biomedical Applications: proc. of the 2th intern. conf., April 18-20, 2013. Chişinău, 2013, pp. 476-479. ISBN 978-9975-62-343-8. en_US
dc.identifier.isbn 978-9975-62-343-8
dc.identifier.uri http://repository.utm.md/handle/5014/5324
dc.description.abstract Background: Type 1 diabetes is a multisystem disease with both biochemical and anatomical consequences. It is a chronic disease of carbohydrate, fat and protein metabolism caused by the lack of insulin, resulting in marked and progressive inability of the pancreas to secrete it because of the autoimmune destruction of beta cells. Diabetes is a widespread disease in the world, reaching a population of 371 million in 2012, of which 5-15% are type I diabetics, most of them children and young people. Cell therapy is a new direction in the treatment of this type of diabetes. Materials and Methods: This experimental study tried using umbilical stem cells and pancreatic cells for the treatment of alloxan induced diabetes in rats. The research was conducted in the Laboratory of Tissue Engineering and Cellular Culture at the State University of Medicine and Pharmacy "Nicolae Testemitanu". The method of extraction of the pancreatic beta cells was developed, then the pancreatic cells were grown, and their ability to produce insulin was rated. The cryopreserved umbilical cells had a viability, which was 91.2 ± 1.8%. The suspension of pancreatic cells and umbilical cells was inoculated intraperitonealy in rats with alloxanic diabetes. Results: It was determined that the in vivo inoculation of umbilical cord blood stem cells and allogeneic pancreatic beta cells normalizes the glucose level in animals with experimental induced type I diabetes, and the animals treated with pancreatic cells had lower blood glucose levels than those treated with umbilical cord blood cells.. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject diabetes en_US
dc.subject experimental study en_US
dc.subject cell therapy en_US
dc.title Experimental cell therapy in type I diabetes en_US
dc.type Article en_US


Files in this item

The following license files are associated with this item:

This item appears in the following Collection(s)

Show simple item record

Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

Search DSpace


Advanced Search

Browse

My Account