Biocompatible SPIONs with Superoxid Dismutase/Catalase Immobilized for Cardiovascular Applications

Abstract

Antioxidant enzymes are involved in the therapy of the cardiovascular diseases associated with increased production of reactive oxygen species (ROS). The enzyme efficiency is dependent on the bioactive molecule’s ability to achieve therapeutically adequate levels at the target site. In this paper, superoxide dismutase (SOD) and catalase, enzymes involved in decomposition of reactive oxygen species, have been immobilized onto superparamagnetic iron oxide nanoparticles(SPIONs) and characterized. FT-IR data, particles mean diameter and zeta potential confirmed the enzymes immobilization onto SPIONs.