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Hepatoprotective Activity of Leaf Extract of Laurus Nobilis L. Against CCL4 Induced Hepatotoxicity in Rats

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dc.contributor.author VARDAPETYAN, H.
dc.contributor.author TIRATSUYAN, S.
dc.contributor.author HOVHANNISYAN, A.
dc.date.accessioned 2020-05-18T13:26:51Z
dc.date.available 2020-05-18T13:26:51Z
dc.date.issued 2015
dc.identifier.citation VARDAPETYAN, H., TIRATSUYAN, S., A. HOVHANNISYAN, A. et al. Hepatoprotective Activity of Leaf Extract of Laurus Nobilis L. Against CCL4 Induced Hepatotoxicity in Rats. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 3rd intern. conf., Sept. 23-26 : Program & Abstract Book , 2015. Chişinău, 2015, p. 99. en_US
dc.identifier.uri https://doi.org/10.1007/978-981-287-736-9_99
dc.identifier.uri http://repository.utm.md/handle/5014/8252
dc.description Access full text - https://doi.org/10.1007/978-981-287-736-9_99 en_US
dc.description.abstract The present study was conducted to evaluate the hepatoprotective activity of ethanolic extract of Laurus nobilis against CCL4 induced liver toxic damage in rats. To evaluate the degree of hepatocyte damage in experimental modeling hepatitis the lipid profile and histochemical assay were determined. Introduction of CCl4 in animals was always carried out in fatal to 36 hours. A single injection of the L. nobilis extract simultaneously with CCl4 leads to 100% survi-vability. L. nobilis leaves extract acts on the liver as a potent scavenger of free radicals to prevent the toxic effects of CCl4 induced hepatotoxicity in rats. Under the influence of CCl4 microscopically normal structure of the liver are violated, the signs of diffuse liver disease with extensive necrosis of he-patocytes, perivascular and pericellular edema are determined. Extract has angioprotective action on the capillary bed of the rat liver, vascular protective effect and prevented the progression of necroinflammation, which can be explained by the presence of antioxidants and antimicrobials both of flavonoids origin, such as quercetin and morin as well as ter-pens and terpenoids. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject ethanolic extracts en_US
dc.subject nobilis extracts en_US
dc.subject hystochemistry en_US
dc.subject hepatotoxicity en_US
dc.subject cholesterol en_US
dc.subject triglycerids en_US
dc.title Hepatoprotective Activity of Leaf Extract of Laurus Nobilis L. Against CCL4 Induced Hepatotoxicity in Rats en_US
dc.type Article en_US


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