Bio-functionalized atelocollagen-polysaccharide hydrogels

Abstract

Extracellular matrix plays numerous roles for anchorage dependent cells this is why mimicking extracellular matrix (ECM) using tissue engineering techniques can be very difficult. Collagen and hyaluronic acid are major components of the ECM, having structural role and also in ECM synthesis, for stimulating cell proliferation, cell migration and adhesion. The structures formed by hyaluronic acid in the ECM have the capacity of entrapping water and ions for tissue hydration.