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Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan

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dc.contributor.author BALAN, V.
dc.contributor.author MOISE, C. I.
dc.contributor.author VERESTIUC, L.
dc.date.accessioned 2020-05-22T10:11:32Z
dc.date.available 2020-05-22T10:11:32Z
dc.date.issued 2019
dc.identifier.citation BALAN, V., MOISE, C. I., VERESTIUC, L. Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 104. ISBN 978-9975-72-392-3. en_US
dc.identifier.isbn 978-9975-72-392-3
dc.identifier.uri https://doi.org/10.1007/978-3-030-31866-6_62
dc.identifier.uri http://repository.utm.md/handle/5014/8324
dc.description Access full text - https://doi.org/10.1007/978-3-030-31866-6_62 en_US
dc.description.abstract Self-assembled particles based on amphiphilic chitosan derivatives represent a promising research area, as remarkable properties of these polymeric structures can significantly improve their biological behaviour of the drug delivery systems. In the same time, biotin has been proposed as an active targeting molecule in anti-tumoral formulations. In this paper, self-assembled submicron particles based on biotinilated N- palmitoyl chitosan and loaded with a chimiotherapeutic agent (Paclitaxel) have been prepared by dialysis method combined with ultrasonication. The composition of the particles has been confirmed by FT-IR Spectroscopy. Paclitaxel loaded particles exhibited narrow size distribution, negative charge, a pH-dependent release profile of drug and redispersion ability in simulated body fluids, features which can be useful in drug delivery applications. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject self-assembled particles en_US
dc.subject biotin en_US
dc.subject chitosan en_US
dc.subject chemotherapeutic agents en_US
dc.subject drug delivery applications en_US
dc.title Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan en_US
dc.type Article en_US


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