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Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan
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| dc.contributor.author | BALAN, V. | |
| dc.contributor.author | MOISE, C. I. | |
| dc.contributor.author | VERESTIUC, L. | |
| dc.date.accessioned | 2020-05-22T10:11:32Z | |
| dc.date.available | 2020-05-22T10:11:32Z | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | BALAN, V., MOISE, C. I., VERESTIUC, L. Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 104. ISBN 978-9975-72-392-3. | en_US |
| dc.identifier.isbn | 978-9975-72-392-3 | |
| dc.identifier.uri | https://doi.org/10.1007/978-3-030-31866-6_62 | |
| dc.identifier.uri | http://repository.utm.md/handle/5014/8324 | |
| dc.description | Access full text - https://doi.org/10.1007/978-3-030-31866-6_62 | en_US |
| dc.description.abstract | Self-assembled particles based on amphiphilic chitosan derivatives represent a promising research area, as remarkable properties of these polymeric structures can significantly improve their biological behaviour of the drug delivery systems. In the same time, biotin has been proposed as an active targeting molecule in anti-tumoral formulations. In this paper, self-assembled submicron particles based on biotinilated N- palmitoyl chitosan and loaded with a chimiotherapeutic agent (Paclitaxel) have been prepared by dialysis method combined with ultrasonication. The composition of the particles has been confirmed by FT-IR Spectroscopy. Paclitaxel loaded particles exhibited narrow size distribution, negative charge, a pH-dependent release profile of drug and redispersion ability in simulated body fluids, features which can be useful in drug delivery applications. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Tehnica UTM | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject | self-assembled particles | en_US |
| dc.subject | biotin | en_US |
| dc.subject | chitosan | en_US |
| dc.subject | chemotherapeutic agents | en_US |
| dc.subject | drug delivery applications | en_US |
| dc.title | Synthesis and Characterization of Self-assembled Submicron Particles Based on Biotinylated N-palmitoyl Chitosan | en_US |
| dc.type | Article | en_US |
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