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Influence of MW Irradiation on the Hydroxyapatite/Chitosan Composite Structure and Drug Release Kinetics

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dc.contributor.author SUKHODUB, L. B.
dc.contributor.author KUMEDA, M. O.
dc.contributor.author SUKHODUB, L. F.
dc.date.accessioned 2020-05-22T10:58:40Z
dc.date.available 2020-05-22T10:58:40Z
dc.date.issued 2019
dc.identifier.citation GINOSYAN, S., HAMBARDZUMYAN, Y., MKRTCHYAN, T. et al. Molecular Docking of Compounds Modulating Amyloid Peptide Aggregation Schemes. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 107. ISBN 978-9975-72-392-3. en_US
dc.identifier.isbn 978-9975-72-392-3
dc.identifier.uri https://doi.org/10.1007/978-3-030-31866-6_64
dc.identifier.uri http://repository.utm.md/handle/5014/8329
dc.description Access full text - https://doi.org/10.1007/978-3-030-31866-6_64 en_US
dc.description.abstract Biocomposite material based on hydroxyapatite (HA) and chitosan (CS) in form of beads was synthesized using microwave irradiation (MW) of different power and investigated by methods of XRD and HPLC. MW reduces the time of HA formation to 20 min without affecting its structure. Liquid absorption and liquid retention for the synthesized at maximum MW power HA-CS-MW800 sample is 27%, while for the control HA-CS 5%. HPLC showed significant differences in the release kinetics of the hydrophilic Chlorhexidine (CHX) and hydrophobic benzocaine (BZ) and proved the composite ability to prolonged drug release to 336 h for CHX and 384 h for BZ. The HA- CS-MW800 demonstrates the highest release rate for CHX and the lowest one for BZ. From HA-CS-MW800 sample in the first 2 hours is released the smallest amount of BZ (about 32%), compared to 45% for others. The effect of MW contributes to the specific location of binding sites in composite and access of drug molecules to these sites. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject hydroxyapatite en_US
dc.subject chitosan en_US
dc.subject microwave irradiations en_US
dc.subject drug release en_US
dc.title Influence of MW Irradiation on the Hydroxyapatite/Chitosan Composite Structure and Drug Release Kinetics en_US
dc.type Article en_US


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