Mode of Artemisinins’ Action on Oxidative Stress, Genomic and G-quadruplex DNA

Abstract

The present study was conducted to evaluate the effect of artemisinins’ on the level of lipid peroxidation (LPO), spontaneous chemiluminescence of the S-180 sarcoma homogenate and to study the nature of the interaction with canonical and non-canonical forms of DNA. Artemisinins are secondary metabolites of the medicinal plant Artemisia annua have anti-inflammatory, anticarcinogenic, immunomodulatory, antimicrobial, antihelminthic, antiviral, antioxidant and other properties. Our preliminary reverse virtual screening demonstrated that the ligand-binding domain of the human glucocorticoid receptor is the optimal target for artemisinin as well as for dexamethasone.