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Remodeling of Cortical Structural Networks in Multiple Sclerosis

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dc.contributor.author CIOLAC, D.
dc.date.accessioned 2020-05-29T11:28:57Z
dc.date.available 2020-05-29T11:28:57Z
dc.date.issued 2019
dc.identifier.citation CIOLAC, D. Remodeling of Cortical Structural Networks in Multiple Sclerosis. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 138. ISBN 978-9975-72-392-3. en_US
dc.identifier.isbn 978-9975-72-392-3
dc.identifier.uri https://doi.org/10.1007/978-3-030-31866-6_88
dc.identifier.uri http://repository.utm.md/handle/5014/8461
dc.description Access full text - https://doi.org/10.1007/978-3-030-31866-6_88 en_US
dc.description.abstract Multiple sclerosis (MS) is one of the most frequent immune-mediated disorders of the central nervous system. Pathological events occurring within the white matter and gray matter compartments can be reliably tracked in vivo by magnetic resonance imaging (MRI) but conventional imaging parameters do not reflect the remodeling processes of the brain. Here, we sought to investigate the reorganization of cortical structural networks in a group of patients with MS. For this, 40 patients (mean age ± standard deviation 31.2 ± 7.0 years, 14 males) with relapsing-remitting MS and 40 healthy subjects (27.1 ± 5.0 years, 14 males) were included in the study. From T1-weighted MR image-derived cortical thickness values, connectivity matrices were generated and network measures of integration and segregation compared between the groups. MS patients presented higher modularity, clustering coefficient and local efficiency but lower global efficiency when compared to healthy subjects. These results indicate that remodeling of cortical structural networks in patients with MS occurs towards the strengthening of intramodular connectivity and local processing. Presumably, this reorganized network architecture topology is an adaptation response required to maintain brain networks’ functionality in conditions of ongoing tissue damage. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject multiple sclerosis en_US
dc.subject sclerosis en_US
dc.subject network architecture en_US
dc.subject graph theory en_US
dc.title Remodeling of Cortical Structural Networks in Multiple Sclerosis en_US
dc.type Article en_US


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