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Mechanical and Morphological Characterization of Decellularized Umbilical Vessels as Tissue Engineering Scaffolds

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dc.contributor.author MALCOVA, T.
dc.contributor.author GLOBA, L.
dc.contributor.author VASCAN, A.
dc.contributor.author ȚUGUI, E.
dc.contributor.author STOIAN, A.
dc.contributor.author NACU, V.
dc.date.accessioned 2020-05-30T07:30:05Z
dc.date.available 2020-05-30T07:30:05Z
dc.date.issued 2019
dc.identifier.citation MALCOVA, T., GLOBA, L., VASCAN, A. Mechanical and Morphological Characterization of Decellularized Umbilical Vessels as Tissue Engineering Scaffolds. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 144. ISBN 978-9975-72-392-3. en_US
dc.identifier.isbn 978-9975-72-392-3
dc.identifier.uri https://doi.org/10.1007/978-3-030-31866-6_105
dc.identifier.uri http://repository.utm.md/handle/5014/8475
dc.description Access full text - https://doi.org/10.1007/978-3-030-31866-6_105 en_US
dc.description.abstract Cardiovascular diseases are the number one cause of morbidity and mortality globally. Numerous pathophysiological modifications that develop are associated with the stenosis and occlusion of blood vessels and tissue damage due to inadequate nutrient supply. Despite a variety of therapies available today, the preferred treatment for the long-term revascularization is artery bypass surgery. The autologous vessels are considered the “gold” standard treatment for this category of patients; unfortunately, they are often unavailable due to comorbidities or unsuitable for use. Synthetic scaffolds are suitable in large-diameter arteries (> 8,0 mm) and medium-diameter arteries (6,0−8,0 mm), but are of limited use in small-diameter vessels (< 6,0 mm) due to poor patency rates. However, tissue engineering may be an option to overcome the existing practical issue. Thus, tissue engineered vascular grafts (TEVGs), namely decellularized matrix, are suggested to present an appropriate graft alternative; as a result, increasing interest is dedicated to this field. By decellularization the loss of major histocompatibility complex (MHC) is induced. Consequently, the risk of development of an immunological response by the host is reduced. Undoubtedly, the acellular scaffolds have a lot of advantages. There are reports about different decellularization techniques already, such as physical, chemical and biological methods. Unfortunately, information about combination and comparison between them are not sufficient. This study aimed to contrast three different methods (the enzymatic method with 0.25% trypsin; the chemical method with 1% SDS and the combined method with 0.25% trypsin and 1% SDS) to decellularize umbilical vessels as a TEVG of a small diameter and test histological and physical properties. In addition, a short overview of advantages and disadvantages of existing protocols is also presented. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject cardiovascular diseases en_US
dc.subject tissue engineering en_US
dc.subject decellularized biological scaffold en_US
dc.subject extracellular matrix en_US
dc.title Mechanical and Morphological Characterization of Decellularized Umbilical Vessels as Tissue Engineering Scaffolds en_US
dc.type Article en_US


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