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Theoretical Model of Lipid Peroxidation Kinetics for Complexes of Cytochrome c and Cardiolipin with Participation of Antioxidants

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dc.contributor.author KANAROVSKII, E. Yu.
dc.contributor.author YALTYCHENKO, O. V.
dc.contributor.author GORINCHOY, N. N.
dc.date.accessioned 2020-05-30T11:11:50Z
dc.date.available 2020-05-30T11:11:50Z
dc.date.issued 2019
dc.identifier.citation KANAROVSKII, E. Yu., YALTYCHENKO, O. V., GORINCHOY, N. N. Theoretical Model of Lipid Peroxidation Kinetics for Complexes of Cytochrome c and Cardiolipin with Participation of Antioxidants. In: ICNMBE: International conference on Nanotechnologies and Biomedical Engineering: proc. of the 4rd intern. conf., Sept. 18-21 : Program & Abstract Book , 2019. Chişinău, 2019, p. 146. ISBN 978-9975-72-392-3. en_US
dc.identifier.isbn 978-9975-72-392-3
dc.identifier.uri https://doi.org/10.1007/978-3-030-31866-6_100
dc.identifier.uri http://repository.utm.md/handle/5014/8479
dc.description Access full text - https://doi.org/10.1007/978-3-030-31866-6_100 en_US
dc.description.abstract It is represented the kinetic model of lipid peroxidation process take place in the lipid membranes owing to a peroxidase activity of the complexes of cytochrome c and cardiolipine. The theoretical description of the studied kinetics includes two pathways: enzymatic and non-enzymatic, and takes into account the presence of direct-acting antioxidant: the molecules that act as the free radical scavengers, directly exhibiting a relatively high antiradical activity. The enzymatic pathway includes the reactions involving the complexes of cytochrome c and cardiolipin. The non-enzymatic pathway includes the reactions involving the free lipid radicals and antioxidant molecules. The obtained system of differential equations allows to simulate the kinetics of the lipid peroxidation process both accounting the inhibitory effect of the antioxidant and without it, and to test the antiradical activity of various types of antioxidants, as well as to find some unknown kinetic parameters by performing a comparison of the theoretical kinetic curves with the experimental ones. en_US
dc.language.iso en en_US
dc.publisher Tehnica UTM en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject cytochrome c en_US
dc.subject cardiolipin en_US
dc.subject lipid peroxidation en_US
dc.subject chemical kinetics en_US
dc.subject free radicals en_US
dc.subject antioxidants en_US
dc.title Theoretical Model of Lipid Peroxidation Kinetics for Complexes of Cytochrome c and Cardiolipin with Participation of Antioxidants en_US
dc.type Article en_US


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