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The Impact of Biogenic Silver Nanoparticles on the Enzymatic Antioxidant System of Wistar Rats’ Kidney

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dc.contributor.author TUMOYAN, Juleta
dc.contributor.author KAZARYAN, Shushanik
dc.contributor.author HOVHANNISYAN, Ashkhen
dc.date.accessioned 2023-11-10T08:25:06Z
dc.date.available 2023-11-10T08:25:06Z
dc.date.issued 2023
dc.identifier.citation TUMOYAN, Juleta, KAZARYAN, Shushanik, HOVHANNISYAN, Ashkhen. The Impact of Biogenic Silver Nanoparticles on the Enzymatic Antioxidant System of Wistar Rats’ Kidney. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 1: Nanotechnologies and Nano-biomaterials for Applications in Medicine, 2023, p. 546-553. ISBN 978-3-031-42774-9. e-ISBN 978-3-031-42775-6. en_US
dc.identifier.isbn 978-3-031-42774-9
dc.identifier.isbn 978-3-031-42775-6
dc.identifier.uri https://doi.org/10.1007/978-3-031-42775-6_58
dc.identifier.uri http://repository.utm.md/handle/5014/24748
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42775-6_58 en_US
dc.description.abstract The objective of this research was to comparatively assess the effects of biogenic AgNPs, stabilized in a 50% extract of O. araratum, on the antioxidant system (AOS) of Wistar rats’ kidney, considering different exposure durations. The activity of superoxide dismutase (SOD), peroxidase (PO), and the concentration of malondialdehyde (MDA) in the kidney homogenate of experimental animals were measured using colorimetric methods. The study revealed that regardless of the duration of exposure, there was an increase in SOD activity. However, PO activity was inhibited, leading to elevated levels of hydrogen peroxide, as indicated by the higher concentration of MDA, after 7 days of exposure to stabilized biogenic AgNPs. On the other hand, exposure for 14 days resulted in the normalization of MDA content. Prolonged exposure to AgNPs reduced the destructive effects of rosmarinic acid (RA) and the extract. These outcomes shed light on the diverse properties of biogenic AgNPs responsible for inducing oxidative stress. However, despite this critical mechanism, protective mechanisms are also observed in vivo during long-term exposure. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject silver nanoparticles en_US
dc.subject enzymatic antioxidant system en_US
dc.title The Impact of Biogenic Silver Nanoparticles on the Enzymatic Antioxidant System of Wistar Rats’ Kidney en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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