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Assessment of Oxidative Stress Markers in Obese Patients with Community-Acquired Pneumonia

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dc.contributor.author DUMITRAS, Tatiana
dc.contributor.author FETCO-MEREUTA, Diana
dc.contributor.author CAPROS, Natalia
dc.contributor.author CHIHAI, Viorica
dc.contributor.author TERNA, Eudochia
dc.contributor.author MATCOVSCHI, Sergiu
dc.contributor.author CASCAVAL, Virginia
dc.date.accessioned 2023-11-16T06:57:01Z
dc.date.available 2023-11-16T06:57:01Z
dc.date.issued 2023
dc.identifier.citation DUMITRAS, Tatiana, FETCO-MEREUTA, Diana, CAPROS, Natalia et al. Assessment of Oxidative Stress Markers in Obese Patients with Community-Acquired Pneumonia. In: 6th International Conference on Nanotechnologies and Biomedical Engineering: proc. of ICNBME-2023, 20–23, 2023, Chisinau, vol. 2: Biomedical Engineering and New Technologies for Diagnosis, Treatment, and Rehabilitation, 2023, p. 384-391. ISBN 978-3-031-42781-7. e-ISBN 978-3-031-42782-4. en_US
dc.identifier.isbn 978-3-031-42781-7
dc.identifier.isbn 978-3-031-42782-4
dc.identifier.uri https://doi.org/10.1007/978-3-031-42782-4_41
dc.identifier.uri http://repository.utm.md/handle/5014/24848
dc.description Acces full text - https://doi.org/10.1007/978-3-031-42782-4_41 en_US
dc.description.abstract Obesity is associated with a low antioxidant defense compared with normal weight. Total antioxidant status is lower in obese than in normal weight adults, and this anti-oxidant imbalance favors systemic oxidative stress. Pneumonia is one of the most common infectious diseases, and the impact of obesity in the development and progression of the disease is well known. However, there are debatable opinions about the association between obesity and pneumonia risk or pneumonia mortality, some of them supporting the obesity survival paradox. The article reflects a clinical study based on initial hypothesis of more expressed pro-oxidative status and worse outcomes in obese patients with community-acquired pneumonia in comparison with normal weight patients. The study included 101 patients with CAP, who were divided into two groups, according to their weight. Serum markers of oxidative stress (advanced oxidation products, malondialdehyde, advanced glycation end products and nitric oxide) as well as pneumonia-related mortality did not differ significantly in obese and normal weight patients. Unlike other antioxidative mark-ers (total antioxidant capacity measured by ABTS method, catalase and thiolic com-pounds), total antioxidant activity measured by CUPRAC method showed a positive correlation with the obesity cases and proved to be an important and promising tool to assess the anti-inflammatory and protective antioxidative activity in community-acquired pneumonia. en_US
dc.language.iso en en_US
dc.publisher Springer Nature Switzerland en_US
dc.rights Attribution-NonCommercial-NoDerivs 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/us/ *
dc.subject oxidative stress en_US
dc.subject community-acquired pneumonia en_US
dc.subject obesity paradox en_US
dc.title Assessment of Oxidative Stress Markers in Obese Patients with Community-Acquired Pneumonia en_US
dc.type Article en_US


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  • 2023
    6th International Conference on Nanotechnologies and Biomedical Engineering, September 20–23, 2023, Chisinau, Moldova

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Attribution-NonCommercial-NoDerivs 3.0 United States Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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