dc.contributor.author | SOCHIRCA, Alexandra | |
dc.contributor.author | SIDORENKO, Ludmila | |
dc.contributor.author | SIDORENKO, Svetlana | |
dc.date.accessioned | 2024-04-25T13:37:22Z | |
dc.date.available | 2024-04-25T13:37:22Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | SOCHIRCA, Alexandra, SIDORENKO, Ludmila, SIDORENKO, Svetlana. Molecular trigger mechanisms for neurodegeneration process via mitophagy in Parkinson’s disease. In: Quo Vadis – Ethics of the Scientific Research: conf. NANO-2024, event devoted to the 60th anniversary of the Technical University of Moldova, 15-18 April 2024, Chişinău, Republica Moldova: Program and proceedings of the conference, Chişinău 2024, pp. 90-91. ISBN 978-9975-64-422-8. | en_US |
dc.identifier.isbn | 978-9975-64-422-8 | |
dc.identifier.uri | http://repository.utm.md/handle/5014/26930 | |
dc.description.abstract | Parkinson’s disease (PD) is a chronically progressing neurodegenerative disorder, which is associated with the following clinical core features bradykinesia, tremor, and rigidity. It is considered the second most common central nervous system degenerative disorder, which occupies the second place after Alzheimer's disease. Its molecular mechanism lies in the process of mitophagy, which is involved in the development of a range of neurodegenerative diseases, and the mutation of PINK1 and Parkin genes. Goal: The evaluation of the molecular background of PD's pathogenesis. Conclusion: Thus, the main molecular mechanism for PD emergence is the accumulation of defective mitochondria, caused by the mutations of PINK1 and Parkin genes, the expression of which dysregulates the mitochondrial activity, leading to the accumulation of the defected mitochondria and disruption of the mitophagy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Technical University of Moldova | en_US |
dc.relation.ispartofseries | NANO-2024 "Quo Vadis – Ethics of the Scientific Research", event devoted to the 60th anniversary of the Technical University of Moldova;15-18 April 2024, Chişinău, Republica Moldova | |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Parkinson’s disease | en_US |
dc.subject | mitochondrial degradation | en_US |
dc.subject | process of mitophagy | en_US |
dc.title | Molecular trigger mechanisms for neurodegeneration process via mitophagy in Parkinson’s disease | en_US |
dc.type | Article | en_US |
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