Effect of plants’ extracts on rat liver against CCL4 intoxication

Abstract

Flavonoids are plant secondary compounds that represent a low molecular polyphenols. They have broad spectrum of biological activity, demonstrating immune modulating, anti-inflammatory, anti-asthma, -cancer and other activities. The impact of phenolic compounds is based on their antioxidant features. The aim of the thesis was to evaluate the antioxidative and hepatoprotective effects of ethanolic extacts of P. major, L. nobilis, O. basilicum in terms of the cytotoxic effects of CCl4 with the simultaneous study of histomorphology and key biochemical indicators of hepatocytes toxic damage. The mechanisms of their effects are monitored, as well as examine the possibility of their use in the treatment of hepatitis of various etiologies.