Effect of Gold and Silver Nanoparticles Functionalized by Cyanobacteria Spirulina platensis on Rats

Abstract

The functionalization of gold and silver nanoparticles with living cells of Spirulina platensis (spirulina) was achieved through adding them to the cyanobacteria nutrient medium and performing a complete cycle of biomass growth. Biomass containing gold or silver nanoparticles in the amount of 1 μg/day versus unmodified nanoparticles stabilized in PEG, was administered to rats for 28 days, followed by a clearance period of the same duration. The accumulation of nanoparticles in different organs, the change in hematological, biochemical and morphometric parameters in the experimental animals were assessed at the end of the nanoparticle administration and the clearance periods.